GLENDALE Gary Zimmerman Jersey , Ariz. — Emmanuel Sanders threw and caught touchdown passes, Denver returned two interceptions for first-quarter touchdowns and the Broncos snapped a four-game losing streak with a 45-10 rout of the Arizona Cardinals on Thursday night.Todd Davis returned rookie Josh Rosen‘s deflected pass for a touchdown on the second play of the game and Chris Harris Jr. took another back 53 yards for a score with 2:02 left in the quarter as the Broncos (3-4) opened a 21-3 lead.Rosen threw three interceptions and fumbled the ball away twice on a rough night that began badly for him and never got better. He limped off the field after he was sacked for the fifth time, on a fourth-and-16 play near the end of the game.The Cardinals (1-6), down 35-3 at the half, fell to 0-4 at home for the first time since 1979.Case Keenum completed 14 of 21 passes for 161 yards and a touchdown with one interception for Denver. Phillip Lindsay rushed for 90 yards on 14 carries, including a 28-yard TD run.Rosen had called a time out after the game’s first play. Then his pass was deflected by the outstretched hand of defensive end Derek Wolfe. The ball dropped into the hands of Davis, who ran it in from there.Arizona followed with a three-and-out and the Broncos quickly made it 14-0 with a six-play, 77-yard drive. Sanders took the ball on an end around and threw to a wide open Courtland Sutton 28 yards for the touchdown.The receiver may have run the wrong route on Rosen’s second “pick six.” In a third-and-one situation from the Arizona 46, Rosen passed but there was no one near the ball except Harris https://www.broncosfanstore.com/Garett-Bolles-Jersey , who returned it 53 yards to make it 21-3.The Broncos made it 28-3 in the second quarter when Keenum found Harris wide open on a 64-yard TD play, the Denver receiver doing a front flip over the goal line.A pass interference play against Bene Benwikere in the end zone set up Royce Freeman‘s one-yard TD run that made it 35-3 with 21 seconds left in the half. The run capped a 15-play, 70-yard drive that used up 6:39.The Arizona fans booed as the team left the field for the half, while there were cheers from the sizable contingent of orange-clad Broncos supporters.FITZ SCORESThe Cardinals got their only touchdown in the third quarter, Rosen throwing four yards to Larry Fitzgerald for the score. Fitzgerald’s first TD catch of the season came at the end of an 11-play, 63-yard drive that followed Patrick Peterson‘s interception. Fitzgerald’s 111 career TDs tie him with Tony Gonzalez for seventh on the NFL’s career list.INJURIESArizona tight end Ricky Seals-Jones, trying to run down Rosen’s fumble, slammed his left forearm against an opponent’s helmet and didn’t return.UP NEXTCardinals host San Francisco on Oct. 28. A few years ago fans were wondering if the Denver Broncos had made the right choice choosing Vance Joseph to be their next head coach over Kyle Shanahan. It’s fair to state that both coaches have struggled in their two seasons leading their respective teams. Under Joseph the Broncos are 11-17 and the San Francisco 49ers are 8-20 at with Shanahan at the helm. Yet to keep perspective, it’s important to point out the status of the teams they both inherited were starkly different.That being said Jake Butt Color Rush Jersey , this year’s Broncos have shown a lot of grit and the ability to overcome adversity. After a 3-6 start, Denver has won three-straight games and are in the middle of a wild race for a playoff berth in the AFC. The 49ers are going the exact opposite direction having lost their last three contests. Both teams have been decimated by injuries this year.A glance at the 49ers’ offenseLast year’s late-season surge of six-straight wins thanks to the performance of Jimmy Garoppolo had their fans excited about the 2018 season. The 49ers had their franchise quarterback and acquired a handful of offensive weapons to help him out in the offseason and draft. That optimism changed to absolute despair when Garoppolo went down with a season-ending ACL injury earlier in the season against the Kansas City Chiefs. In place of Garoppolo, the 49ers turned to second-year quarterback C.J. Beathard who is now on the sidelines with a wrist injury.The man leading the 49ers into battle on Sunday is Nick Mullens, the all-time record holder in every passing category at Southern Miss who went undrafted in 2017. In his first game this season against the Oakland Raiders, Mullens threw for 262 yards, 3 touchdowns and completed 72 percent of his passes. In their three-game losing streak since defeating the Raiders, Mullens has come back down to earth and has thrown just 4 touchdowns to 5 interceptions in that span.The injury bug isn’t just limited to the quarterback position for San Francisco. They will be without their best offensive weapon in running back Matt Breida who is ruled out for Sunday’s affair with an ankle injury. That’s extremely bad news for them considering their rushing attack was one of the best in the league and the focal point of their offense. Additionally, long-time veteran wide receiver Pierre Garcon didn’t practice on Thursday and could be out as well. If so, that means Marquise Goodwin and rookie Dante Pettis will be the two main attractions at wide receiver this weekend. However Billy Turner Jersey , their most effective receiving option has been former Iowa product George Kittle, who has been a revelation for them at tight end. He has 62 receptions for 893 yards and 3 touchdowns so far this season and is playing at a Pro-Bowl level. That is the player Broncos’ fans should worry the most about offensively on Sunday.The bane of their offense has been their penchant for turnovers. They have only have 5 takeways on the season, but have given up the ball 25 times (15 interceptions and 10 fumbles). That has severely hurt their chances to win games and often resulted in points scored for opposing teams who have had the benefit of playing on short fields. With the Broncos’ key to success being takeaways over the past few weeks, their game against the 49ers presents a great opportunity to continue that trend.A glance at the 49ers’ defenseThe story of the 2018 49ers defensively is an odd dichotomy. While the 49ers defense ranks in the middle league-wide with respect to yardage allowed through the air and on the ground, they are near the bottom of the league with respect to points. I’ve outlined a major reason why that is above due to their offense turning the ball over. All and all, giving up 28 points a game isn’t a recipe for success.Another key issue defensively is their inability to get pressure on opposing quarterbacks. They also rank in the bottom portion of the league when it comes to sacks with just 29 on the season. DeForest Buckner, arguably their best player on defense has 9 sacks, but no other player on the roster has more than 4.5. There’s little doubt that edge rusher is a huge need for the franchise moving forward considering they have had no quality production or consistency this year at the position.Their secondary isn’t filled with household names and could use an infusion of talent, but Case Keenum should be cognizant of Richard Sherman at cornerback. One of the bright spots for their defense has been the play of rookie inside linebacker Fred Warner who has 92 tackles on the season. Isolating Warner and keeping him in check will be important for the Broncos’ offense if they want to run the ball effectively.Keys to the gameWith the recent news regarding Emmanuel Sanders https://www.broncosfanstore.com/Tramaine-Brock-Jersey , I want to see how the Broncos’ young receivers perform with more snaps and opportunities. Courtland Sutton going up against Richard Sherman is a battle I’m eager to watch. Additionally, I’m hoping to see some big things from DaeSean Hamilton. Those two need to win their one-on-one battles to help propel the Broncos’ offense.I fully expect the Broncos to give the 49ers’ defense a healthy dose of Phillip Lindsay and Royce Freeman as well. The Broncos’ offensive line has been dominant in run blocking as of late so it will be interesting to see how they perform against the aforementioned Buckner, as well as Solomon Thomas and the rest of their defensive line. This should be the focal point of the Broncos’ offensive game-plan considering Sanders’ injury.Another key aspect to watch is how Bradley Chubb does against Joe Staley, as well as Von Miller going up against rookie offensive tackle Mike McGlinchey, who has been very impressive as a starter. If they can dial up the heat and put pressure on Mullens, I foresee a handful of takeaways being generated by the Broncos’ defense tomorrow afternoon. Hart’s PredictionI’ll keep this short and sweet. The 49ers are arguably the worst team in the league and are in the midst of a battle for the number one pick in the 2019 NFL Draft. The Broncos are a team on the rise hoping to overcome recent injuries and make the postseason. Denver is hot, the 49ers are not. I’m confident that Denver will be able to do enough to win their fourth-straight game and inch closer to securing a wildcard berth.Broncos 27, 49ers 17.